Published papers meeting the above reported criteria are mainly searched through the following electronic databases: PubMed/Medline, the Cochrane library, PsycINFO and PsycARTICLES.
After having verified eligibility of articles, at least two reviewers (i.e., study collaborators) independently review and extract several information. Each reviewer has a personal password to access the online system and can complete the electronic-data extraction form (eDEF). This approach allows a double blind data entry procedure to ensure the highest possible quality data collection in the PROMOTION Registry. Discrepancies in the two evaluations are recorded and a discrepancy Form is electronically generated by the data collection system. On the basis of this discrepancy Form the two reviewers discuss each issue by revisiting the paper to reconcile any differences. When consensus is achieved on each single variable, a final eDEF (for that specific article) is then locked, validated and imputed in the PROMOTION database.
More than 50 different information (i.e., variables) are included in the eDEF. Data extracted for each RCT includes:
Lastly, a summary of clinical and PRO data is also extracted from each paper reviewed.
To date several hundreds of studies published since January 2004 have been included in the DB. See more details hereunder:
|Cancer Disease sites||Published Until||Nr. of RCTs|
|Head & Neck||June 2015||66|
|Liver primary||March 2013||9|
|Lung (Non-Small Cell Lung)||December 2017||123|
|Myelodysplastic syndromes||December 2013||7|